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Omtrent seven-9 % af den kaukasiske befolkning har variationer i CYP2D6 genet som koder for ingen- eller nedsat aktivitet af CYP2D6 (se personlig medicin ). Tramadol et produg der omdannes til den aktive metabolit by using CYP2D6. Patienter med nedsat eller manglende aktivitet af CYP2D6, vil have reduceret- eller manglende effekt af tramadol.Eksper
I don’t don't forget precisely how much time it was. But it had been right after I noticed that he experienced dropped out and in advance of I received dwelling in the pool that he had endorsed Harris.He argued the criticism from both sides was “a very good sign” that indicated the law was crafted with “a way of proportion.”The federal go